Bioorthogonal

Compositions and methods for modular control of bioorthogonal ligation
The present invention provides a compound having the structure- Formula (I) wherein R1 is H or a protecting group; R2 and R3 are each …
Last updated on Feb 17, 2025
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Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
We describe a modular activation strategy for cyclopropene-tetrazine ligation. This activation strategy uses chemically diverse enzyme- …
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Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate
As a neurotransmitter, the amino acid glutamate has been the subject of efforts to generate structural analogs with unique properties. …
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Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate
Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until …
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Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Modular Activatable Bioorthogonal Reagents
The bioorthogonal reaction toolbox contains approximately two-dozen unique chemistries that permit selective tagging and probing of …
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Modular Activatable Bioorthogonal Reagents
Caged Cyclopropenes for Controlling Bioorthogonal Reactivity
Bioorthogonal ligations have been designed and optimized to provide new experimental avenues for understanding biological systems. …
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Caged Cyclopropenes for Controlling Bioorthogonal Reactivity
A Photocaged, Cyclopropene-Containing Analog of the Amino Acid Neurotransmitter Glutamate
Substituted cyclopropenes serve as compact biorthogonal appendages that enable analysis of biomolecules in complex systems. …
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A Photocaged, Cyclopropene-Containing Analog of the Amino Acid Neurotransmitter Glutamate