Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation

Abstract

We describe a modular activation strategy for cyclopropene-tetrazine ligation. This activation strategy uses chemically diverse enzyme- or photolabile protecting groups as cyclopropene reactivity cages. The linkages between the caging groups and cyclopropene are through carbamates, thus permitting the application of diverse cages to allow bioorthogonal reactivity by administering enzymes or light.

Ting Jiang

PhD student

Pratik Kumar

Assistant Professor - Reader F

Wei Huang

PhD student

Wei-Siang Kao

PhD student

Frank M. Camarda

Undergraduate student