Tetrazine

Compositions and methods for modular control of bioorthogonal ligation
The present invention provides a compound having the structure- Formula (I) wherein R1 is H or a protecting group; R2 and R3 are each …
Last updated on Jun 13, 2026
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Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
We describe a modular activation strategy for cyclopropene-tetrazine ligation. This activation strategy uses chemically diverse enzyme- …
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Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until …
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Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Modular Activatable Bioorthogonal Reagents
The bioorthogonal reaction toolbox contains approximately two-dozen unique chemistries that permit selective tagging and probing of …
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Modular Activatable Bioorthogonal Reagents
Caged Cyclopropenes for Controlling Bioorthogonal Reactivity
Bioorthogonal ligations have been designed and optimized to provide new experimental avenues for understanding biological systems. …
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Caged Cyclopropenes for Controlling Bioorthogonal Reactivity