Abstract
Lipidated cyclopropenes serve as useful bioorthogonal reagents for imaging cell membranes due to the cyclopropene’s small size and ability to ligate with pro-fluorescent tetrazines. Previously, the lipidation of cyclopropenes required modification at the C3 position because methods to append lipids at C1/C2 were not available. Herein, we describe C1/C2 lipidation with the biologically active lipid ceramide and a common phospholipid using a cyclopropene scaffold whose reactivity with 1,2,4,5-tetrazines has been caged.
Publication type
Publication
Tetrahedron Letters, 59(37), 3435-3438
Pratik Kumar
Assistant Professor - Reader F
Ting Jiang
PhD student
Omar Zainul
Undergraduate student
Sining Li
MS student
