Article-Journal

Optimizing multifunctional fluorescent ligands for intracellular labeling
Enzyme-based self-labeling tags enable covalent attachment of synthetic molecules to proteins inside living cells. A frontier of this …
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Optimizing multifunctional fluorescent ligands for intracellular labeling
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain
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Live imaging of the extracellular matrix with a glycan-binding fluorophore
All multicellular systems produce and dynamically regulate extracellular matrices (ECM) that play essential roles in both biochemical …
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Live imaging of the extracellular matrix with a glycan-binding fluorophore
Lipid Expansion Microscopy
Strategies to visualize cellular membranes with light microscopy are restricted by the diffraction limit of light, which far exceeds …
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Lipid Expansion Microscopy
2,7-Diaminobenzopyrylium Dyes are Live-Cell Mitochondrial Stains
Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we …
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2,7-Diaminobenzopyrylium Dyes are Live-Cell Mitochondrial Stains
Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
We describe a modular activation strategy for cyclopropene-tetrazine ligation. This activation strategy uses chemically diverse enzyme- …
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Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate
As a neurotransmitter, the amino acid glutamate has been the subject of efforts to generate structural analogs with unique properties. …
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Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate
Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until …
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Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Lipidated Cyclopropenes via a Stable 3-N Spirocyclopropene Scaffold
Lipidated cyclopropenes serve as useful bioorthogonal reagents for imaging cell membranes due to the cyclopropene’s small size …
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Lipidated Cyclopropenes via a Stable 3-N Spirocyclopropene Scaffold
Caged Cyclopropenes for Controlling Bioorthogonal Reactivity
Bioorthogonal ligations have been designed and optimized to provide new experimental avenues for understanding biological systems. …
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Caged Cyclopropenes for Controlling Bioorthogonal Reactivity