Article-Journal

Live imaging of the extracellular matrix with a glycan-binding fluorophore
All multicellular systems produce and dynamically regulate extracellular matrices (ECM) that play essential roles in both biochemical …
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Live imaging of the extracellular matrix with a glycan-binding fluorophore
Single-cell synaptome mapping of endogenous protein subpopulations in mammalian brain
Lipid Expansion Microscopy
Strategies to visualize cellular membranes with light microscopy are restricted by the diffraction limit of light, which far exceeds …
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Lipid Expansion Microscopy
2,7-Diaminobenzopyrylium Dyes are Live-Cell Mitochondrial Stains
Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we …
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2,7-Diaminobenzopyrylium Dyes are Live-Cell Mitochondrial Stains
Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
We describe a modular activation strategy for cyclopropene-tetrazine ligation. This activation strategy uses chemically diverse enzyme- …
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Modular Enzyme- and Light-Based Activation of Cyclopropene-Tetrazine Ligation
Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate
As a neurotransmitter, the amino acid glutamate has been the subject of efforts to generate structural analogs with unique properties. …
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Stable Cyclopropene-Containing Analogs of the Amino Acid Neurotransmitter Glutamate
Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Activatable cyclopropenes are unreactive toward their inverse electron demand Diels-Alder reaction partner (e.g., s-tetrazines) until …
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Caged Cyclopropenes with Improved Tetrazine Ligation Kinetics
Lipidated Cyclopropenes via a Stable 3-N Spirocyclopropene Scaffold
Lipidated cyclopropenes serve as useful bioorthogonal reagents for imaging cell membranes due to the cyclopropene’s small size …
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Lipidated Cyclopropenes via a Stable 3-N Spirocyclopropene Scaffold
Caged Cyclopropenes for Controlling Bioorthogonal Reactivity
Bioorthogonal ligations have been designed and optimized to provide new experimental avenues for understanding biological systems. …
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Caged Cyclopropenes for Controlling Bioorthogonal Reactivity
Inexpensive Multigram-Scale Synthesis of Cyclic Enamines and 3-*N* Spirocyclopropyl Systems
Cyclic enamines are important synthons for many synthetic and pharmacological targets. Here, we report an inexpensive, catalyst-free, …
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Inexpensive Multigram-Scale Synthesis of Cyclic Enamines and 3-*N* Spirocyclopropyl Systems